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ADHD Medication Meta-analysis
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Visual Abstract

Methylphenidate Reduces State Anxiety During a Continuous Performance Test That Distinguishes Adult ADHD Patients From Controls

Ritalin reduces anxiety in cognitive test

Yuval Bloch , Shai Aviram , Aviv Segev , Uri Nitzan , Yechiel Levkovitz , Yoram Braw , Aviva Mimouni Bloch
Summarized by:
Charles Li, MD
July 17, 2023
πŸ”Ž
What they studied
Researchers wanted to see whether anxiety was an underlying factor in ADHD and response to methylphenidate, the generic version of Ritalin.
πŸ‘¨β€πŸ”¬
What they found
The ADHD medication in the study improved focus for those with and those without ADHD. It also reduces anxiety in those with ADHD.
πŸ’‘
What this means
These results provide evidence that anxiety may play a key role in ADHD, and may drive some of the benefits of ADHD medication. Reducing anxiety may help students with ADHD at school.

Ritalin reduces anxiety in cognitive test
Methylphenidate Reduces State Anxiety During a Continuous Performance Test That Distinguishes Adult ADHD Patients From Controls

Objectives

ADHD is a complex condition that we are still in the process of understanding. We know that many have difficulties with attention, but it’s not yet entirely clear why.

Some experts theorize that anxiety and distress play a role in ADHD symptoms.

This is consistent with the high rates of anxiety disorders found in those with ADHD:

Based on this theory, researchers wanted to see whether ADHD medication, in this case, Ritalin, could decrease anxiety during testing.

Study Quote
Bloch et al. 2017. J Atten Disord.

We hypothesized that patients with ADHD were typified by distress more than by functional difficulties. Thus, a decline in state anxiety while performing a cognitive task when taking methylphenidate would discriminate between ADHD patients and controls.

Methods

Researchers conducted a small trial using a continuous performance test, one of the most commonly used cognitive test types to help diagnose ADHD.

This test measures a person's ability to stay focused and attentive while avoiding distraction. Those with ADHD tend to struggle with this.

Study Quote
Bloch et al. 2017. J Atten Disord.

State anxiety and cognitive performance on a continuous performance test were assessed in ADHD patients and controls with and without taking methylphenidate.

Results

The results showed that both those with ADHD and those without ADHD improved cognitive performance when provided with methylphenidate, the generic form of Ritalin.

Regardless of ADHD status, Ritalin helped participants focus on the continuous performance task.

However, only those with ADHD showed improvements in anxiety during the test.

A small crossover trial found that Ritalin increased cognitive performance in those with and without ADHD. However, it only improved anxiety in those with ADHD.

Study Quote
Bloch et al. 2017. J Atten Disord.

State anxiety and cognitive performance improved from baseline in 36 ADHD adults after taking methylphenidate. In 25 controls, cognitive performance improved, but state anxiety did not abate after a recess. In two additional studies, 5 controls were evaluated at baseline and after receiv...

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Conclusions

These results provide evidence that many of the symptoms we associate with ADHD, particularly in the classroom, may come as a result of anxiety. Test anxiety can get in the way of performance at school and work.

One of the mechanisms behind ADHD medication might be its effect in reducing anxiety in those with ADHD.

Study Quote
Bloch et al. 2017. J Atten Disord.

Our results support the hypothesis that adult ADHD patients are characterized by distress and the relief of this distress under effective therapy as expressed by a decline in state anxiety while they perform a cognitive task.