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Visual Abstract

Predictors of persistence of ADHD into adulthood: a systematic review of the literature and meta‐analysis

Predictors of ADHD Persistence in Adulthood

Arthur Caye , Alex V Spadini , Rafael G Karam , Eugenio H Grevet , Diego L Rovaris , Claiton H D Bau , Luis A Rohde , Christian Kieling
Summarized by:
Charles Li, MD
April 22, 2023
study source
European Child & Adolescent Psychiatry
March 2016
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What they studied
Many children with ADHD continue to have ADHD as adults. This study looked at which factors can predict who gets better.
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What they found
Researchers found that those with severe ADHD and those with other conditions, such as major depressive disorder, were far more likely to have ADHD persist into adulthood.
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Key takeaways
Studies like this one help doctors identify the kids who might need the most help with their ADHD. It also suggests ways to improve the chances of someone getting better.

Predictors of persistence of ADHD into adulthood: a systematic review of the literature and meta‐analysis

Background

While ADHD improves over time, many will experience some ADHD symptoms even after they grow into adults.

However, there has not been a lot of research on what factors make it more likely for someone to experience persistent ADHD.

Study Quote
Caye et al. 2016

Attention-deficit/hyperactivity disorder (ADHD) is traditionally conceptualized as a neurodevelopmental disorder that continues into adulthood in up to half of diagnosed cases. In light of current evidence, factors associated with the course of the disorder remain unknown.

Method

Researchers in this study collected data from 16 other studies that looked at potential risk factors for ADHD persistence into adulthood.

These studies looked back over time at the pasts of those with ADHD. They also included data from follow-ups of childhood ADHD studies.

Study Quote
Caye et al. 2016

We performed a systematic review of the literature searching for risk markers from childhood that predicted the persistence of ADHD into adulthood. We reviewed 26,168 abstracts and selected 72 for full-text review. We identified data from 16 studies, comprising 6 population-based retrosp...

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Results

Researchers found four factors that were significantly linked with persistent ADHD. Children with ADHD, who had any of these factors, were at a much higher risk of continuing to have ADHD as adults.

For example, children with severe ADHD were more than twice as likely to have ADHD when they reached adulthood compared to someone who did not have severe ADHD.

It’s important to keep in mind, however, that these are correlations rather than causations. They show us statistical links between factors, but they don’t necessarily show whether one factor causes another. For example, the second most significant factor found was ADHD treatment. However, it’s unlikely that ADHD treatment itself is directly causing ADHD persistence.

Correlation and Causation
A meta-analysis found that severe ADHD, ADHD treatment, conduct disorder, and major depressive disorder were all factors linked to someone having ADHD persisting into adulthood.

Researchers also examined factors such as IQ, gender, and socioeconomic status. None of these other factors were significantly linked with ADHD persistence. Boys were not necessarily more likely to have ADHD persist to adulthood than girls.

Study Quote
Caye et al. 2016

We performed meta-analyses of factors evaluated by at least three studies. Severity of ADHD (OR 2.33, 95 % CI = 1.6-3.39, p < 0.001), treatment for ADHD (OR 2.09, 95 % CI = 1.04-4.18, p = 0.037), comorbid conduct disorder (OR 1.85, 95 % CI = 1.06-3.24, p = 0.030), and comorbid major depr...

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Conclusions

The authors suggest that we may need more studies to understand the risk factors for ADHD persistence better. The data in this study were gathered from studies conducted for other purposes. A study specifically designed to examine ADHD persistent risk factors will tell us more about ways we can help children get better from their ADHD symptoms.

Study Quote
Caye et al. 2016

Further, we suggest that cohort studies should be designed to clarify such an important question for research and clinical practice.