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Visual Abstract

Irritability in ADHD: Associations with depression liability

Olga Eyre , Kate Langley , Argyris Stringaris , Ellen Leibenluft , Stephan Collishaw , Anita Thapar
Summarized by:
Charles Li, MD
April 23, 2023
study source
J Affect Disord
June 2017
🔥
What they studied
Researchers wanted to see whether ADHD was linked to irritable moods, and whether these moods could be linked with depression as well.
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What they found
Nearly all of the children in the study, had frequent, irritable moods. 31% met the criteria for an irritable mood disorder.
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What this means
This study provide solid evidence that links irritable moods and ADHD. It also suggests a possible link between irritable moods and having depression with ADHD.

Irritability in ADHD: Associations with depression liability

Background

Irritability and bad moods have been associated with ADHD, though they are not diagnostic criteria for ADHD.

Medical experts are starting to recognize a new disorder called Disruptive Mood Dysregulation Disorder. This new diagnosis provides a name for having disruptively angry or irritable moods.

As a newly recognized disorder, there hasn’t been much research on it.

Researchers in the study wanted to understand more about the link between DMDD and ADHD. They also wanted to understand whether children with ADHD and DMDD have different rates of other mental health conditions, such as depression and anxiety.

What is DMDD?

DMDD is characterized by severe and inappropriate outbursts. Typically, someone with DMDD may also be angry in between outbursts.

These episodes begin between ages six and 18. This is similar to the current understanding of ADHD, in which symptoms typically start in adolescence.

It’s important to note that not every bad mood counts as a disorder. It’s entirely normal to feel irritated and angry at times. This disorder is meant to capture a seriously disruptive condition that affects normal daily function.

“
The core feature of disruptive mood dysregulation disorder is chronic, severe persistent irritability. This severe irritability has two prominent clinical manifestations, the first of which is frequent temper outbursts. These outbursts typically occur in response to frustration and can be verbal or behavioral
DSM-5
Study Quote
Eyre et al. 2017

Irritability and the new DSM-5 diagnostic category of Disruptive Mood Dysregulation Disorder (DMDD) have been conceptualised as related to mood disorder. Irritability is common in Attention Deficit Hyperactivity Disorder (ADHD) but little is known about its association with depression ri...

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Methods

Researchers recruited 696 children who had a diagnosis of ADHD. They asked these children questions to measure levels of irritability, anxiety, and depression.

They also surveyed the parents for depression and asked about family histories of depression.

Study Quote
Eyre et al. 2017

The sample consisted of 696 children (mean age 10.9 years) with a diagnosis of ADHD, recruited from UK child psychiatry and paediatric clinics. Parents completed the Child and Adolescent Psychiatric Assessment, a semi-structured diagnostic interview, about their child. This was used to e...

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Results

Researchers found that most of the kids in the study experienced irritability. This tells us that irritability is common among kids with ADHD. However, because it doesn’t compare this finding to kids without ADHD, it’s hard to say how strong the link is between ADHD and irritability. One of the downsides of this type of study is that we can’t rule out the possibility that most kids are irritable regardless of ADHD status based on the measurements that they used.

Researchers also found that 31% of the children in the study with ADHD also met the criteria for the new irritability disorder. This is a surprisingly high prevalence for any disorder. The authors, however, did note that the data comes from a group of children already diagnosed with ADHD which suggests that the data may not be generalizable to the general population.

A study on children with ADHD found that most had experienced irritability symptoms. 31% met the criteria for an irritability mood disorder.

Those with ADHD and the new irritability disorder generally had worse outcomes. They had more anxiety symptoms and depression symptoms and were more likely to have depression run in their family.

A study on children with ADHD found that most had experienced irritability symptoms. 31% met the criteria for an irritability mood disorder.

Study Quote
Eyre et al. 2017

Irritability was common, with 91% endorsing at least one irritable symptom. 3-month DMDD prevalence was 31%. Children with higher levels of irritability or DMDD were more likely to have comorbid symptoms of anxiety, depression and a family history of depression...

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Conclusions

This study provides evidence of a substantial link between ADHD and a new irritability disorder.

Many parents and teachers of those with ADHD have known for a while that ADHD can affect irritability and moods. This data provides evidence that supports their hunch.

The link between irritable moods and depression is concerning, but we will need more research to know how strong this link is and how it evolves as kids get older.

Study Quote
Eyre et al. 2017

Irritability and DMDD were common, and were associated with markers of depression liability. Longitudinal studies are needed to examine the association between irritability and depression in youth with ADHD as they get older.