#nutrition

Folic Acid & Stroke

By Charles Li, MD

Background

You've probably heard that you should eat fruits and vegetables to get your vitamins. But, what exactly is the evidence behind this?

Key Facts
Folic Acid
key facts
  • Other Names
    Vitamin B9
  • Daily Amount
    400 micrograms
  • Nutrient Type
    B Vitamin
Appearance
used for

Pregnancy

Mental Health

Stroke

What is Folic Acid?

Folic Acid helps your body rebuild itself. Like a hammer or a drill, folic acid is a tool that your body uses to create new parts and fix old parts.


Folic Acid is considered a B-vitamin, along with Vitamin B1, B2, B3, etc. You may have also seen Folic Acid referred to as Vitamin B9.

Expert Opinion
Folic Acid vs Folate

"The terms “folic acid” and “folate” often are used interchangeably. However, folate is a general term used to describe the many different forms of vitamin B9…Folic acid is the synthetic (that is, not generally occurring naturally) form of folate that is used in supplements and in fortified foods, such as rice, pasta, bread, and some breakfast cereals."

Read more: CDC

Study 1: Folic Acid & Stroke

Folic Acid & Stroke
Folic acid has been linked to a 10% lower risk of stroke

Folic acid supplements have been linked to a significantly lower risk of stroke and cardiovascular disease in general. 


 The Journal of the American Heart Association analyzed 30 clinical trials, involving 82,334 participants. They found that those given folic acid supplements were around 10% less likely to suffer a stroke compared to those who were not given folic acid.

Finding #1
Folic Acid & Stroke
Risk of Stroke
-10%
Baseline
No Supplements
With Folic Acid
0.9x (0.84-0.96)
Meta-analysis
30 trials
82,334 participants
Study Source
From the abstract:

"Our meta‐analysis indicated a 10% lower risk of stroke and a 4% lower risk of overall CVD with folic acid supplementation."

Li et al, JAHA

Folic Acid & Cardiovascular Disease

Folic Acid and Heart Disease
Folic Acid supplements lower your risk of heart disease by 4%.

Researchers found that taking folic acid overall leads to a 4% lower risk of cardiovascular disease.


While this wasn't a huge difference, it was still found to be statistically significant.

Cardiovascular disease is a large category of disease that covers heart attacks, strokes, and other conditions involving your blood vessels.

Finding #2
Folic Acid & Cardiovascular Disease
Cardiovascular Disease Risk
-4%
Baseline
Baseline Risk without Folic Acid Supplements
Risk with Folic Acid
96x
Meta-analysis
30 studies
n=82,334