SLI381 was effective in treating children with ADHD throughout the day in natural home and school settings. This medication offers a safe, long-lasting option that helps control ADHD symptoms not just during school, but also during after-school activities and family time. The treatment was well tolerated with few side effects. It also showed consistent benefits for both boys and girls with ADHD, making it a promising choice for many young patients. A once-a-day dose simplifies medication routines for children, improving compliance and ensuring they remain focused all day long.

Researchers conducted a rigorous, multicenter trial involving 47 sites, where children aged 6 to 12 diagnosed with ADHD participated. After a week-long break from any previous stimulant medication, participants were randomly assigned to receive either a placebo or one of three doses of Adderall XR (10 mg, 20 mg, or 30 mg) each morning for three weeks.

The study measured effectiveness primarily through the Conners Global Index Scale for Teachers and also considered parents' assessments, clinical impressions, and overall improvements from parents' perspectives. Safety was closely monitored through reports of adverse events, lab tests, and physical exams, including ECGs taken at both the beginning and end of the study.

Out of 584 children who entered the study, 563 were part of the analysis, and 509 completed the trial. The findings showed that all doses of Adderall XR significantly improved behaviors in the morning, afternoon, and late afternoon compared to the placebo group. This improvement was consistent across teacher and parent ratings and was dose-dependent, with higher doses leading to greater behavioral improvements.

In terms of overall impression and parental assessments, Adderall XR outperformed the placebo across all doses by the study's end, confirming the relationship between higher doses and better outcomes. Additionally, the rate of reported adverse events was low and comparable between those on Adderall XR and those on placebo, indicating a favorable safety profile.

Adderall XR demonstrated clear, dose-related improvements in children's behavior throughout the day. The study confirmed that this extended-release formulation is effective in providing consistent symptom control in the morning, afternoon, and even late afternoon, as observed by both teachers and parents.

The consistent therapeutic effect throughout the day suggests that Adderall XR is a reliable once-daily treatment option for managing ADHD in children, providing substantial benefits without a significant increase in adverse effects compared to a placebo.