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Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study
ADHD Genetic Risk, Household Chaos, and Symptoms
December 5, 2024
author
Agnew-Blais JC, Wertz J, Arseneault L, Belsky DW, Danese A, Pingault JB, Polanczyk GV, Sugden K, Williams B, Moffitt TE
journal
J Child Psychol Psychiatry
Date Published
2022 Oct
chart icon Visual
Original
Study Summary
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What They Studied
Researchers investigated whether chaotic households contribute to more ADHD symptoms in children and if ADHD genetic risks influence household chaos.
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What They Found
The study discovered that children in chaotic households tend to have more ADHD symptoms, and both mothers and children with higher genetic risks for ADHD also lived in more chaotic conditions.
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What This Means
These findings suggest that children's genetic risks for ADHD may play a role in how chaotic their home environment becomes, providing insight beyond existing studies which largely focused on medication treatments like Methylphenidate and Adderall.
Study Overview
Background & Objectives
The drug methylphenidate, commonly known as Ritalin, is widely used for treating ADHD, significantly influencing neurotransmitter activity. Recently, a study sought to explore links between chaotic home settings and ADHD symptoms in children.

The researchers investigated if genetic predispositions for ADHD could increase household chaos, impacting ADHD symptoms in kids. This study delves into the interactions between genetic factors and residential disorder.
Abstract: background
Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic ...more
Study Summary
Methods
The study involved mothers and their twins from a group of 2,232 children representative of the UK population. ADHD symptoms were tracked through various age milestones: 5, 7, 10, and 12 years old.

Household chaos was assessed through researchers' ratings and self-reports from mothers and twins. Genetic risk, indicated by ADHD polygenic risk scores, was evaluated for mothers and children to understand their correlation with household chaos.
Abstract: methods
Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative bir...more
Study Results
Results
The study found that children in chaotic households exhibited more ADHD symptoms, even when accounting for genetic risks. Both mothers and children with higher genetic predisposition to ADHD experienced more home chaos.

Children's genetic makeup was more closely tied to household chaos than that of the mothers, suggesting an interaction where genetics and environment influence each other. Nonetheless, chaos had a significant impact on ADHD progression.
Abstract: results
Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic household...more
Study Summary
Conclusions
Genetic risk in children independently correlates with increased levels of home chaos, indicating children might shape their home environment. This connection raises questions about whether home chaos directly affects core ADHD symptoms.

Findings stress the need to factor in genetic elements from both parents and children when evaluating environmental influences, suggesting that what is perceived as environmental may partly be determined genetically.
Abstract: conclusions
Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic r...more
Visual Summary for Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study
Clinical Guidelines
Guidelines suggest that environmental factors typically affect ADHD behavior only in specific settings, like at home.

A chronic illness approach may aid parents with ADHD.

Family-school partnerships support ADHD management.
Literature Review
Jaffee et al, 2012
Core Insight:Both studies explore how home environment impacts children's behavior, highlighting genetic and environmental influences.
What It Adds:
Environmental Mediation: This paper finds household chaos affects behavior through environmental factors.
Genetic Influence on Chaos: This paper suggests chaos heritability is not due to genetic behavior influences.
Key Differences:Main paper links genetic risk to household chaos; this paper focuses on environmental mediation.
Literature Review
Wirth et al, 2019
Core Insight:Household chaos connects children's ADHD with parenting.
What It Adds:
Indirect effects confirmed: Finds ADHD influences parenting via household chaos.
Different focus: Examines emotional climate, not just genetic factors.
Additional Section:
Shared Themes: Both studies link ADHD to household chaos.
Literature Review
Fisher et al, 2015
Core Insight:The main paper links ADHD genetic risk and household chaos, suggesting possible gene-environment interplay influencing ADHD symptoms. In contrast, this paper finds environmental factors predominantly influence children's activity levels, despite the presence of some genetic influences.
What It Adds:
Explores gene-environment roles: Main paper suggests gene-environment interplay in ADHD, while this paper emphasizes environmental impact on activity.
Shared environmental insights: Both papers analyze environmental influences, shedding light on how home and other settings affect children.