Stimulant medications have been shown to offer symptomatic improvement (particularly in attention and on-task behaviors) as well as improvement in daily functioning (vocational and interpersonal performance) in adults as compared with placebo.

It is generally accepted that the efficacy of the amphetamines is not different from that of methylphenidate, which is the other major stimulant used to treat ADHD.

Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses for ADHD.

Other adverse events evoked by the amphetamines include nausea, vomiting, abdominal cramps, increases in blood pressure and heart rate and possibly also the exacerbation of motor tics.

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment: slow or difficult speech, dizziness, weakness or numbness of an arm or leg, seizures, motor or verbal tics, teeth grinding, depression, believing things that are not true, feeling unusually suspicious of others, hallucinating (seeing things or hearing voices that do not exist).

Occasional case reports indicate that prescription use can produce marked psychological adverse events, including stimulant-induced psychosis.,High doses of amphetamines can produce psychotic behavior indistinguishable from schizophrenia in asymptomatic schizophrenics and in some healthy human subjects.

Most pharmaceutical amphetamine is used in treatment of ADHD. Although the therapeutic mode of action is not fully known, amphetamine is highly efficacious for the reduction of core ADHD symptoms in children, adolescents, and adults.

Other common side effects of amphetamine include insomnia, headache, dry mouth, tachycardia, increase in systolic blood pressure, restlessness, and irritability.